Harnessing the Power of Vitamin B3 (Nicotinamide) in the Fight Against Actinic Keratosis and Skin Cancer


In the quest for effective strategies to combat skin cancer, recent research has shed light on the remarkable role of Vitamin B3, specifically nicotinamide, in reducing the incidence of actinic keratosis (AK) and various forms of skin cancer. This blog post explores the findings of medical studies supporting this discovery, the recommended dosage for optimal results, proposed mechanisms of action, and the specific patient populations that stand to benefit the most from this promising therapy.


Medical Studies Supporting the Role of Nicotinamide:

Numerous clinical studies have provided compelling evidence regarding the efficacy of nicotinamide in reducing the risk of skin cancer, particularly actinic keratosis and certain non-melanoma skin cancers. One notable study published in the New England Journal of Medicine in 2015 revealed that high-dose oral nicotinamide demonstrated a significant reduction in the rates of new non-melanoma skin cancers and actinic keratoses in high-risk individuals. The study involved a randomized, double-blind trial, adding substantial credibility to the potential benefits of nicotinamide.


The Stats:

In the 2015 study, a group of patients taking 500 mg of nicotinamide twice a day were compared to another group taking a placebo. After 1 year, patients who took the vitamin had a 23% reduction in the development of new Basal Cell Carcinoma and Squamous Cell Carcinoma skin cancers.

Specifically, by taking nicotinamide, there was a 20% reduction in the the development of new basal cell carcinoma, 30% reduction in new squamous cell carcinoma, and 13% reduction in actinic keratoses. Reductions in risk were noted as soon as 3 months after starting vitamin therapy. The benefits also ceased after stopping the treatment.


Dosage Recommendations:

The dosage required to achieve a reduction in skin cancer incidence has been a focal point of research. According to studies, a daily oral dose of nicotinamide ranging from 500 to 1500 milligrams has demonstrated effectiveness in various trials. It is essential to note that individuals should consult with their healthcare providers before incorporating nicotinamide into their routine, as the optimal dosage may vary based on individual factors.


Proposed Mechanism of Action:

The precise mechanism by which nicotinamide exerts its protective effects on the skin is still under investigation. However, researchers propose that nicotinamide may influence cellular energy production, DNA repair processes, and immune system function. Additionally, nicotinamide is known for its anti-inflammatory properties, which could play a role in mitigating the impact of UV radiation on skin cells, reducing the risk of cancerous transformations.


Patients Who Would Benefit Most:

While nicotinamide holds promise for a broad spectrum of individuals, certain patient populations may derive particular benefits. Individuals with a history of actinic keratosis, those with fair skin, and individuals with a heightened susceptibility to non-melanoma skin cancers due to factors such as prolonged sun exposure or immunosuppression could benefit significantly from nicotinamide therapy. However, it is crucial for healthcare providers to assess each patient’s unique risk factors and medical history to tailor recommendations appropriately.



The emergence of Vitamin B3, specifically nicotinamide, as a potential ally in the fight against actinic keratosis and skin cancer marks a significant stride in dermatological research. As evidenced by robust clinical studies, nicotinamide showcases a promising ability to reduce the incidence of skin cancers, providing hope for individuals at heightened risk. Nevertheless, ongoing research is vital to further elucidate the mechanisms at play and refine dosage recommendations. As nicotinamide continues to be explored as a preventive measure, individuals should collaborate closely with their healthcare providers to determine the most suitable approach for their unique skin health needs.

Contact Us
Map Call